Jul 2, - When I started taking antidepressants, my depression finally receded. Unfortunately, so did my orgasms. Antidepressants and inhibited female orgasm: a literature review. Male sexual dysfunctions associated with antidepressant medication have been frequently reported. Much less common, however, are reports of sexual problems in women who are taking antidepressants. A case of anorgasmia secondary to trazodone is presented.