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Nov 9, - A CSHP study involving 2, women examined their use of water-based or silicone-based lubricants during sexual activity. The use of lubricants during sexual activity has been recommended as a strategy to reduce the likelihood of vaginal tearing, which can increase risk for HIV and other STI. Dec 10, - Still, most of the recent lab-based safety studies conducted on personal lubricants fall short of indicting the products. “We have signals that are.