Mar 7, - The most commonly used anti-androgen for treating hirsutism is spironolactone (Aldactone). Because these drugs can cause birth defects, it's important to use contraception while taking them. Topical cream. Eflornithine (Vaniqa) is a prescription cream specifically for excessive facial hair in women. Aug 17, - Of all the beauty treatments out there, removing your facial hair (or any hair, for that matter) is one of the least pleasant activities — but it doesn't.